Facing longtime rival Israel Adesanya for the UFC Middleweight Championship, Pereira entered with confidence, having already defeated Adesanya twice in kickboxing. The fight was a back-and-forth war, with Adesanya controlling much of the action and even rocking Pereira at the end of the first round. However, Pereira’s power remained a threat, and in the fifth round, he walked Adesanya down, landed a brutal combination against the cage, and secured the knockout. With this win, Pereira became the UFC Middleweight Champion in just his eighth professional MMA fight (though Adesanya would eventually get his revenge at UFC 287).